Nakhon Phanom University is a state university which has been institutionalized by the integrations of various colleges and schools. The University has been officially established since September 2, 2005 under Nakhon Phanom University Act, published in the Government Gazette Vol. 122, Part 75A, dated 1st September, 2005.
Article 4 of the act provided that Nakhon Phanom University is constituted with Nakhon Phanom Rajabhat University, Mahasarakham university Nakhon Phanom Campus, Nakhon Phanom Technical College, Nakhon Phanom College of Agriculture and Technology, Thatphanom Industrial and Community Education College, Nawa Industrial and Community Education College, and Boromarajonani College of Nursing. As a result, Nakhon Phanom University is a legal entity and is part of the government working under the Office of the Higher Education Commission.